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Dermaroller Hyaluronic Acid Serum Box
Dermaroller Hyaluronic Acid Serum Box

Dermaroller’s HLA Serum is an easy-to-use sterile 1.5 ml ampoule that contains hyaluronic acid (HLA) and a synergistic blend of ingredients that stimulate stem cell proliferation.

Hyaluronic Acid  (HLA) is an essential component of our tissues and extracellular matrix with a complex set of roles. It plays a vital role in cell proliferation and cell migration. In simple words, it is essentially a complex chain of sugar molecules (otherwise known as a polysaccharides, specifically glycosaminoglycans polymers) produced by our body. It has a tremendous capacity to bind and hold onto water. 1 gram (0.035 ounces) of pure HLA can bind up to 6 litres (203 ounces) of water. Unfortunately, as we age our body’s HLA production decreases and our skin begins to form wrinkles. In order to compensate for this natural loss, HLA must be replaced. Therefore, HLA is widely used in aesthetic medicine in the form of “fillers”. Since HLA is a very large molecule with a high molecular weight, it cannot easily penetrate the skin (Stratum Corneum, SC) and must be injected. This expensive and at times, uncomfortable experience, can last 3 to 6 months and sometimes longer depending on the injection technique, HLA type and quality injected, and on individual skin type and requirements.

As an alternative to injections, the SC can easily and safely be “opened” and penetrated by micro-needles. The HLA can then easily diffuse into the deeper skin layers. Of course, the longer the needles the deeper it can be deposited, however, HLA settles at depth of 0.5 to 0.6 mm below the epidermis. Therefore, the Home Care Dermaroller with its 0.2 mm micro-needles is definitely sufficient to infiltrate HLA while in the comfort of your home.

HLA is often touted for its ability to "reverse" or stop aging. In news reports, you might have heard of hyaluronic acid as the “key to the fountain of youth.” This is because the substance occurs naturally (and quite abundantly) in humans and animals, and is found in joint fluid, other tissues and young skin.

HLA is a component of the body’s connective tissues, and is known to cushion and lubricate. As you age, however, the forces of nature destroy hyaluronic acid. Medical conditions, diet, stress, pollutants and smoking will affect your body’s level of hyaluronic acid over time. Skin care products with hyaluronic acid are most frequently used to treat wrinkled skin.

HLA is an important natural component of skin produced by skin cells called fibroblasts. The number of active fibroblasts decreases as you age. Skin starts losing hyaluronic acid as early as age 18, but wrinkles and other evidence of skin damage from hyaluronic acid loss doesn’t generally appear until the late 30s or early 40s. Preserving or regaining hyaluronic acid is a goal of many skin care scientists and specialists. Developing products that can help with these tasks can keep the skin supple and youthful-looking.

HLA is a natural compound found in skin that has many important functions, including retaining moisture, providing cushioning, aiding in tissue repair, holding together the skin structural components collagen and elastin, and helping create a protective barrier against microorganisms.

Dermaroller's HLA Serum is an advanced, one of a kind formulation, that includes the purest source of HLA mixed together with synergistic cofactors. This powerful product is one of the only commercially available sterile HLA available in the United States. Unlike common HLA skin care creams, this form of HLA is sterile, and does not contain animal proteins, preservatives, parabens, petrochemicals, or fragrance. It is safe to be used in conjunction with ablative and non-ablative medical procedures.

Along with the HLA are common synergistic nutrients that will increase the efficacy of the HLA:

UREA:  It also has excellent water binding properties and a positive effect on dry skin. It is a fact that micro-needles mechanically remove ie. exfoliate old skin scales from the epidermis, and urea smooths the skin.  It has potent skin care benefits that refine the skin texture and makes the skin appear healthy and younger looking.

It boosts the process of protein synthesis in the body and supplies essential nitrogen contents. It is a natural moisturizer that is found within the skin. This is why dry skin has very low levels of urea.

Urea contents in the body prove to be very advantageous for the skin as they promote antibacterial and antiviral properties. In addition, since urea boosts antimicrobial properties, urea based skin care products require fewer preservatives.

Urea reduces the amount of water that is lost through the skin's epidermis and retains skin moisture for a longer period of time. Since urea also has a very high water-binding capacity it helps to keep the skin well-moisturized. It also acts as an effective humectant and attracts moisture to the skin, especially the dry areas. In fact, it is a natural moisturizing factor (NMF) present in the outer layers of the skin. Due to its NMF property, it is extremely beneficial for skin conditions like eczema and psoriasis. In essence, it helps to keep moisture in the skin and thickens the epidermis.

Urea helps to accelerate the process of skin cell and skin regeneration process. This strengthens the barrier function of the skin and keeps it healthy. A strong skin barrier ensures stronger resistance against potential irritants. Because urea acts on the skin's barrier, it promotes better absorption and penetration of other ingredients in skin care products into the skin surface.

Urea based skin care products are ideal for individuals with dry skin. This is because it has excellent moisturizing abilities for most parched skin surfaces. With regular use, the skin becomes soft and supple. The dry patches will diminish. In addition, the skin texture improves and it becomes more resilient.

TOCOPHERYL ACETATE: It is also known as Vitamin E. It is an excellent trapper of free radicals that are triggered by UVA and UVB. Tocopheryl Acetate is a form of Vitamin E, a natural skin conditioning agent and antioxidant. It is the ester of Acetic Acid and Tocopherol. It is often used as an alternative to pure Tocopherol (or undiluted Vitamin E) because it is considered more stable and less acidic.

Tocopheryl Acetate is a fat-soluble vitamin that can be isolated from vegetable oils. It is also found in dairy products, meat, eggs, cereals, nuts, and leafy green and yellow vegetables. Its substantiated benefits include enhancing the efficacy of active sunscreen ingredients, reducing the formation of free radicals from exposure to UV rays, promoting the healing process, strengthening the skin's barrier function, protecting the skin barrier's lipid balance, and reducing transepidermal water loss. Attributed with antioxidant, anti-aging, moisturizing, anti-inflammatory, and enhanced SPF properties, Tocopherol Acetate is valued both as a dietary supplement and skincare active. It is used in a variety of cosmetic and personal care products, including lipstick, eye shadow, blushers, face powders and foundations, moisturizers, skin care products, bath soaps and detergents, and hair conditioners.

As an antioxidant superstar, Vitamin E is one of the most well-researched antioxidants. It is available in eight different forms, which can be extracted from nature or synthetically produced. When the Vitamin E molecule is derived form natural sources, it is preceded by a "d" prefix (e.g. d-alpha-tocopherol); when it is created synthetically, this is indicated by a "dl" prefix (e.g. dl-alpha tocopherol acetate). According to an article in the November 2001 issue of Nutrition Science News, research indicates that the body synthesizes natural Vitamin E far better than synthetic versions. A 2003 study in the American Journal of Clinical Nutrition showed that natural forms of Vitamin E have a higher potency and retention rate than their synthetic derivatives (Source). Nonetheless, all forms of Tocopheryl Acetate deliver antioxidant benefits.

Though all members of the Vitamin E family are fat-soluble, Tocopherol is the most bioavailable, and thus the most readily absorbed by the body. Tocotrienols, comprised of both Tocopherols and Tocotrienols, are the most complete form of Vitamin E. They are endowed with potent neuroprotective, anticancer, and cholesterol-reducing properties not exhibited by Tocopherols because of their distribution in the fatty layers of the cell membrane. Some research points to Tocotrienols, administered orally, as superior sources of antioxidant activity (Source).

ALLANTOIN:  Supports cell  regeneration  and  soothes  the  skin.  It supports cell regeneration and soothes the skin by increasing the water content of the extracellular matrix and enhancing the desquamation of upper layers of dead skin cells, increasing the smoothness of the skin; promoting cell proliferation and wound healing; and a soothing, anti-irritant, and skin protectant effect by forming complexes with irritant and sensitizing agents.

RETINYL-PALMETATE:  It  is  an  ester  of  retinol.  After  it  was  absorbed  by  the  skin  retinyl   palmitate  is  converted  into  retinol,  and  ultimately  to  retinoic  acid,  the  active  form  of  VitL amin  A).  It  also  plays  an  important  role  in  cell  proliferation. 

It belongs to the family of chemical compounds known as Retinoids and is one of the most important vitamins for the appearance of the skin because of its small molecular structures. These tiny molecules have the ability to penetrate the outer layers of the skin and work to repair the lower layers where collagen and elastin reside (Source).


You can apply the Sterile HLA Serum in two ways:

Post-Medical Dermaroller® (or Any Other Medical Skin Procedure)

After you have completed rolling the face with the Medical Dermaroller, make sure to completely remove the numbing cream and clean the face. Then, apply the HLA over the treated areas. Be sure to use more serum around scars, wrinkles or other trouble areas of the skin. If you choose to use the Dermaroller® HLA Mask put the mask on the skin after you have used the HLA Serum.

Post- Home Roller ... in the Comfort of Your Home

Micro-needling the skin – even with the fine, short needles of the Home Dermaroller® or Beauty Mouse® (0.2 mm needle length) – stimulates the proliferation of keratinocytes and fibroblasts, thickening the epidermis and stimulating the production of collagen VI and VII which are important in maintaining the integrity of the skin. (See paper of Lilly Fan and Don Owen)

Micro-needles open the stratum corneum (SC) for about 10-15 minutes – sufficient time for the HLA Serum to be applied to allow the actives of the serum to penetrate the SC and to reach the deeper layers of the skin.

Dermaroller's HLA Serum ingredients are oil-free and non-comedogenic, acting as a hydrating layer when applied prior to commonly-used moisturizers.

The most effective way to use the serum is to have the patient put the serum on after they’ve finished rolling their face. Patients can use more of the serum around scars, wrinkles or other trouble areas of the skin.

The serum can also be combined with the Cool Mask™. Apply the HLA Serum first, the Cool Mask second, and then – if desired – night creams or moisturizers.

Using the HLA Serum 2-3 times per week, along with the Home Roller or Beauty Mouse®, helps to increase the serum's effectiveness and achieve maximum skin hydration, resulting in a smoother, healthier-looking, radiant appearance.

This serum can be used in conjunction with any other medical skin procedures like Laser, medical peels, or microdermabrasion. This will help to increase hydration that was lost during and after the procedure.


DIRECTIONS FOR USE: Wash your face with a cleanser and rinse. Hold 1 ampoule and with a circular motion spinning the vial so that all the contents are at the bottom of the ampoule. Hold the bottom of the ampoule while snapping the top off. After you have micro-needled an area of your face or body with the Home Roller or Beauty Mouse®, apply small amounts of the serum on clean fingers and rub the HLA DR Serum® in a circular motion into the target area. Before the serum dries, roll the home micro-needle roller over the area where the serum was applied. It can be used effectively around the eyes, eyelids, and crow’s feet. It can be applied up to 4-5 times a week, usually at night. However, it is recommended that it be used 2-3 times a week until your skin has time to adapt to the serum. It should not be used with products containing quaternary ammonium salt solutions, such as benzalkonium chloride, which precipitates hyaluronic acid. HLA DR Serum® is supplied in a sterile single-use ampoule and should be discarded after each use. Do not apply the Home Roller or Beauty Mouse® on infected areas or sites with active acne. Should you have any questions or concerns, please contact your medical provider.

"I chose Dermaroller ® due to it's impecable reputation and widespread use throughout Europe. I have seen Dermaroller ® time and time again win awards for standard of care. "
Ira Lee NP
Dermaroller Practitioner
See More Testimonials >
"As a integrative doctor when I saw what the Dermaroller ® was doing with my patient's energy and the increases blood flow to her face I knew that this was an amazing device. The women that I trained on had major acne scars. "
Jorge Moreno DO
Dermaroller Practitioner
See More Testimonials >
"My client's, co-workers, and myself are amazed and thrilled with my results. "
Maggie Griffith , HairArts Spa
"I recommend Dermaroller treatments to my friends all the time. "
Tammy H , Medical Dermaroller Patient

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"Where do I go to see if a micro-needling company is Registered with the FDA?"
"Am I safe even if a micro-needling company claims that it is FDA registered?"
"Can any one perform medical micro-needling?"
"Can I achieve the same results if I use a micro-needling device at home?"
"There are a lot of companies claiming to be FDA Approved. Is Dermaroller® FDA Approved?"
"If I use my micro-needling device more frequently will I achieve better results?"
"Are thinner needles like acupuncture needles better?"
"Are all micro-needling device needles engineered the same?"
"If a roller has more and longer needles, will I get better results?"
"Can micro-needling devices be cleaned or sterilized for repeated home use?"
"Can a medical micro-needling device be reused?"
"Is the Dermaroller® a CE marked medical device? Are any of the alternative skin needle-rollers CE marked?"
"Why should I use a trained practitioner and an authorized Dermaroller® Clinic?"


I chose Dermaroller ® due to it's impecable reputation and widespread use throughout Europe. I have seen Dermaroller ® time and time again win awards for standard of care.

As a integrative doctor when I saw what the Dermaroller ® was doing with my patient's energy and the increases blood flow to her face I knew that this was an amazing device. The women that I trained on had major acne scars.